Synthesis and spectral studies of some new pyrazolines and pyrazoles

A number of 3' -[3-aryl-2-methyl] pyrrol-5-yll-l' - aryl-2 propen-l'-ones 4-13 have been prepared and transformed into the corresponding arylhydrazones 14-28. These hydrazones were cyclized to the pyrazolines 29-43, which were oxidized to the corresponding pyrazoles 49-53. In addition, heating of the pyrazoline 42 with hydrazine hydrate afforded the hydrazide 46 while pyrazolines 41 and 42 gave the acids 47 and 48 upon hydrolysis. Spectral properties of the prepared compounds were discussed

Synthesis and spectral studies of 3-benzoyl-1, 2-dimethyl-5- [5-aryl-1, 3, 4-oxadiazol-2-yl] pyrrole

It has been reported that 2-amino-2-deoxy-D-glucose hydrochloride condense with benzoylacetone to afford either 1 or 2 and it was shown tentatively [1] that structure 1 was the obtained one and this was confirmed earlier by us[2] as well as the work performed in our laboratory[3-6]

Synthesis and reactions of 3-substituted-2-methyl-5-furfural-acetone and ethyl-2,4-dioxo-6- [3'-Ethoxy carbonyl-2'methyl-furan-5'-yl] hex-5-enoate

3-Ethoxycarbonyl-2-methyl-5-furfuralacetone and the 3-acetyl analogue have been prepared. Their reactions with acyl and arylhydrazines and isomerisation of the prepared hydrazones to pyrazolines was carried out, which were converted to the corresponding brominated pyrazole derivatives by the action of bromine-water. In addition, ethyl-2, 4-dioxo-6-[3-ethoxycarbonyl-2-methylfuran-5-yl]hex-5-enoate was prepared and reacted with hydrazines to afford the corresponding pyrazole 3-esters. The structure of the newly prepared compounds was confirmed by, elemental analysis, Hnmr, uv and ir spectra

Studies on some 2-thiophenecarboxaldehyde-aroylhydrazones

A tautomerism involving some 2-thiophenecarboxaldehyde-aroylhydrazones [I-V] was investigated using IR, and MS spectroscopy. Oxidative cyclization of compound IV using yellow mercuric oxide, magnesium oxide and iodine mixture gave the corresponding 1, 3, 4-oxadiazole VI

Mass spectra of furan-aroylhydrazone and 1,3,4-oxadiazole derivatives

Mass spectral fragmentation patterns of some furan derivatives; namely, 3-erhoxycarbonyl-2-methyl-5-formyl-5 aroylhydrazones, 3-acetyl-2-methyl-5-formyl-5-benzoylhydrazone and 3-acetyl-2-methyl-5 [2-phenyl-1,3,.4-oxadiaz ol-5-yl] furans have been analyzed and discussed. It was found that the mode of fragmentation is affected by electronic effect of the substituent

Synthesis of thiosemicarbazones, thiazolines and thiazolidinones derived from Theophylline as potential anticancer agents

A series of novel thiosemicarbazone derivatives of theophylline was Synthesized, then cyclized to the corresponding thiazoline and thiazolidinone derivatives with the aim of obtaining new anticancer agents with diminished toxicity

Synthesis and reaction of 5- [6,6-dimethyl-1-4-oxo4, 5,6,7-teteahydroindol-2-yl] -1,3-diarylpyrazolines

A number of 3-[6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindol-2-yl]-1- aryl-2-propen-1-ones II-V have been prepared and transformed into the corresponding arylhydrazones VI-XI. The latter compounds were cyclized to the pyrazolines XII-XX, which were oxidized the corresponding pyrazoles XXI-XXIV. The spectral properties of the prepared compounds were discussed

Reactions of 6,6-dimethol-4-oxo-4,5,6,7-tetrahydro-2- [D-ara-Binotetrahydro xybutyl] indole

Various hydrazones, thiosemicarbazone and imino derivatives of 6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2 [D-arabinotetrahydroxybutyl] indole have been successfully synthesized and some of the products were acetylated into the tetraacetate derivatives. IR, PMR and 13C- NMR spectra of some products were studied